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KMID : 1134820080370040445
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 4 p.445 ~ p.451
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Effects of Onion Kimchi Extract Supplementation on Blood Glucose and Serum Lipid Contents in Streptozotocin-induced Diabetic Rats
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Yang Ya-Ru
Kim Hag-Lyeol
Park Yang-Kyun
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Abstract
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The purpose of this study was carried out to examine the effects of onion kimchi extract supplementation
on blood glucose level and serum lipid components in streptozotocin (STZ)-induced diabetic rats for 4 weeks.
STZ was administered as a single dose (50 mg/kg BW) to induce diabetes, and the diabetic rats were divided
into eight groups (normal, diabetic control, and six treatment groups). The dose of onion kimchi extract 100
(OK-100), 200 (OK-200), and 400 (OK-400) mg/kg/day or quercetin as a main compound of onion 5 (Q-5),
10 (Q-10), and 20 (Q-20) mg/kg/day were orally administered daily to STZ-induced diabetic rats for 4 weeks
after STZ injection. The diabetic control rats (465.6 mg/dL) showed significantly higher blood glucose level
than the normal rats (76.3 mg/dL) after 4 weeks, but was significantly reduced with onion kimchi extract
and quercetin supplementation (p<0.001). Changes in body weight, kidney weight and urine volume were not
significantly different in diabetic control rats, and in onion kimchi extract and quercetin treated rats. The
serum total cholesterol levels of control were significantly decreased in onion kimchi extract and quercetin
supplementation groups, respectively (p<0.001). The blood urea nitrogen level and urinary protein excretion
in diabetic rats were not significant different among the groups. These results suggest that onion kimchi extract
supplementation in STZ-induced diabetic rats may be a very important factor for the reduction of blood glucose
and serum cholesterol profiles.
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KEYWORD
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onion kimchi extract, quercetin, diabetic rats, blood glucose, serum lipid profiles
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